| 2021-04-11 13:00:00April 11, 2021 |  Junior United FC vs Wesselton Teenagers FC | 2 - 1 | Nkonjaneni Ground |
| 2021-04-11 13:00:00April 11, 2021 | Breyten Stars FC vs MLG Ladies FC | 9 - 0 | Kwazanele Stadium |
| 2021-04-11 15:00:00April 11, 2021 | Breytan Home Sweepers vs Mayflower FC | 1 - 1 | Breytan Laerskool Ground |
| 2021-04-11 15:00:00April 11, 2021 | Breyten Stars FC vs VOC United FC | 0 - 2 | Kwazanele Stadium |
| 2021-04-11 15:00:00April 11, 2021 | Losta Stars FC vs No Fear FC | 1 - 3 | Nkonjaneni Ground |
| 2021-04-11 15:00:00April 11, 2021 |  Flymingo United FC vs Mafia FC | 2 - 0 | Kwantombazana Ground |
| 2021-04-11 15:00:00April 11, 2021 | Silobela United FC vs Fernie Battalion FC | 2 - 3 | Caroline Rugby Ground |
| 2021-04-11 15:00:00April 11, 2021 | Steynsdorp Ajax FC vs Black Stone FC | 0 - 1 | Steynsdorp Sports Ground |
| 2021-04-11 15:00:00April 11, 2021 | Ravens FC vs Davel Young Bees FC | 1 - 0 | Enhlanzatshe No 2 |
| 2021-04-11 15:00:00April 11, 2021 | Barcelona FC vs Manzana FC | 1 - 5 | Fernie B Ground |
| 2021-04-11 15:00:00April 11, 2021 | Pull Together Ladies FC vs Sasol Thistle Grove FC | 1 - 1 | China 2 Amersfoort Ground |
| 2021-04-11 15:00:00April 11, 2021 | Royal FC Ladies vs PSG Santos Ladies FC | 0 - 2 | Daggakraal no. 3 Stadium |
| 2021-04-11 15:00:00April 11, 2021 | Inter Roses Ladies FC vs Home Ladies | 0 - 2 | Extension 18 Ground Embalenhle |
| 2021-04-11 15:00:00April 11, 2021 | Broom Lions Ladies FC vs Sasol Juventus Ladies FC | 0 - 8 | Sizakele Sport Ground |
| 2021-04-11 15:00:00April 11, 2021 | Stars of Tomorrow Ladies FC vs Two For Joy Ladies FC | 1 - 1 | Gate 8 Embalenhle |
| 2021-04-11 15:00:00April 11, 2021 | Amabhubesi Ladies FC vs Royal Knight Ladies FC | 0 - 7 | Basement Ground |
| 2021-04-11 15:00:00April 11, 2021 | Passion Ladies FC vs Stellen Ladies FC | 3 - 1 | Caroline Town Hockey Ground |
| 2021-04-11 15:00:00April 11, 2021 | 305 Eagles Ladies FC vs Real D Stars FC | 2 - 0 | Court Ground |
| 2021-04-11 15:00:00April 11, 2021 | L&B Sports Ladies FC vs Mt Valencia Ladies FC | 0 - 2 | Kromkrans Sport Ground |
| 2021-04-18 13:00:00April 18, 2021 | VOC United FC vs Flymingo United FC | 2 - 1 | Mpumalanga Stadium |
| 2021-04-18 13:00:00April 18, 2021 | Silobela United FC vs Steynsdorp Ajax FC | 1 - 0 | Caroline Rugby Ground |
| 2021-04-18 13:00:00April 18, 2021 | Passion Ladies FC vs Breyten Stars FC | 2 - 0 | Caroline Town Hockey Ground |
| 2021-04-18 13:00:00April 18, 2021 | MLG Ladies FC vs Mt Valencia Ladies FC | 0 - 6 | Chresismeer Stadium |
| 2021-04-18 15:00:00April 18, 2021 | Mayflower FC vs Breyten Stars FC | 1 - 1 | Mayflower Ground |
| 2021-04-18 15:00:00April 18, 2021 | Breytan Home Sweepers vs Losta Stars FC | 3 - 1 | Breytan Laerskool Ground |
| 2021-04-18 15:00:00April 18, 2021 | No Fear FC vs Junior United FC | 0 - 1 | Chressismeer Stadium |
| 2021-04-18 15:00:00April 18, 2021 | Mafia FC vs Wesselton Teenagers FC | 0 - 2 | Mpumalanga Stadium |
| 2021-04-18 15:00:00April 18, 2021 | Fernie Battalion FC vs Somhlolo United | 1 - 0 | Lindza Sport Ground |
| 2021-04-18 15:00:00April 18, 2021 | Black Stone FC vs Barcelona FC | 1 - 0 | Enkaba Sport Ground |
| 2021-04-18 15:00:00April 18, 2021 | Davel Young Bees FC vs Manzana FC | 3 - 0 | Davel Stadium |
Goodwill Promising FC