| 2021-04-11 13:00:00April 11, 2021 |  Junior United FC vs Wesselton Teenagers FC | 2 - 1 | Nkonjaneni Ground |
| 2021-04-11 13:00:00April 11, 2021 | Breyten Stars FC vs MLG Ladies FC | 9 - 0 | Kwazanele Stadium |
| 2021-04-11 13:00:00April 11, 2021 | Flamingo FC vs TS Galaxy Ladies FC | 0 - 2 | Half-Way Grounds |
| 2021-04-11 13:00:00April 11, 2021 | Butterfly Ladies FC vs Super Strikers Ladies FC | 0 - 2 | Zamani Primary |
| 2021-04-11 13:00:00April 11, 2021 | Bushbuckridge Ladies FC vs TK Stars Ladies FC | 2 - 0 | Thulamahashe New Stadium |
| 2021-04-11 13:00:00April 11, 2021 | Chosen Few FC vs Losta Stars Ladies FC | 3 - 4 | Siyazenzela Stadium |
| 2021-04-11 13:00:00April 11, 2021 | Two Touch FC vs Saint Mary's Ladies FC | 5 - 0 | Mandlethu Ground |
| 2021-04-11 13:00:00April 11, 2021 | Sasol Juventus Ladies FC vs Silindile Ladies FC | 3 - 0 | Embalenhle Sasol Club |
| 2021-04-11 13:00:53April 11, 2021 | Likazi Ladies FC vs Mashamplan Ladies FC | 2 - 1 | |
| 2021-04-11 13:00:57April 11, 2021 | FC Royal Knights vs Leandra United FC | 0 - 1 | |
| 2021-04-11 15:00:00April 11, 2021 | Breytan Home Sweepers vs Mayflower FC | 1 - 1 | Breytan Laerskool Ground |
| 2021-04-11 15:00:00April 11, 2021 | Breyten Stars FC vs VOC United FC | 0 - 2 | Kwazanele Stadium |
| 2021-04-11 15:00:00April 11, 2021 | Losta Stars FC vs No Fear FC | 1 - 3 | Nkonjaneni Ground |
| 2021-04-11 15:00:00April 11, 2021 | Silobela United FC vs Fernie Battalion FC | 2 - 3 | Caroline Rugby Ground |
| 2021-04-11 15:00:00April 11, 2021 | Steynsdorp Ajax FC vs Black Stone FC | 0 - 1 | Steynsdorp Sports Ground |
| 2021-04-11 15:00:00April 11, 2021 | Ravens FC vs Davel Young Bees FC | 1 - 0 | Enhlanzatshe No 2 |
| 2021-04-11 15:00:00April 11, 2021 | Barcelona FC vs Manzana FC | 1 - 5 | Fernie B Ground |
| 2021-04-11 15:00:00April 11, 2021 | Pull Together Ladies FC vs Sasol Thistle Grove FC | 1 - 1 | China 2 Amersfoort Ground |
| 2021-04-11 15:00:00April 11, 2021 | Royal FC Ladies vs PSG Santos Ladies FC | 0 - 2 | Daggakraal no. 3 Stadium |
| 2021-04-11 15:00:00April 11, 2021 | Inter Roses Ladies FC vs Home Ladies | 0 - 2 | Extension 18 Ground Embalenhle |
| 2021-04-11 15:00:00April 11, 2021 | Broom Lions Ladies FC vs Sasol Juventus Ladies FC | 0 - 8 | Sizakele Sport Ground |
| 2021-04-11 15:00:00April 11, 2021 | Stars of Tomorrow Ladies FC vs Two For Joy Ladies FC | 1 - 1 | Gate 8 Embalenhle |
| 2021-04-11 15:00:00April 11, 2021 | Amabhubesi Ladies FC vs Royal Knight Ladies FC | 0 - 7 | Basement Ground |
| 2021-04-11 15:00:00April 11, 2021 | Passion Ladies FC vs Stellen Ladies FC | 3 - 1 | Caroline Town Hockey Ground |
| 2021-04-11 15:00:00April 11, 2021 | 305 Eagles Ladies FC vs Real D Stars FC | 2 - 0 | Court Ground |
| 2021-04-11 15:00:00April 11, 2021 | L&B Sports Ladies FC vs Mt Valencia Ladies FC | 0 - 2 | Kromkrans Sport Ground |
| 2021-04-17 09:00:06April 17, 2021 | Young Tigers FC vs Bayern Munich FC | 0 - 2 | Kantombazana Ground |
| 2021-04-17 09:00:09April 17, 2021 |  Citizen FC vs PR Barcelona FC | 3 - 2 | Eziphunzini Ground |
| 2021-04-17 09:00:42April 17, 2021 |  Mafred United FC vs Silver Stars FC | 1 - 1 | Masenkeni Stadium |
| 2021-04-17 09:00:56April 17, 2021 | Welverdiend Stars FC vs Bayern Munich FC | 0 - 0 | Masenkeni Stadium |
