| 2021-08-07 09:00:00August 7, 2021 |  Citizen FC vs Mangosuthu Sundowns FC | 09:00:009:00 am | Eziphunzini Ground |
| 2021-08-07 09:00:00August 7, 2021 | Paris St. Germain FC vs Young Zebras FC | 09:00:009:00 am | Masenkeni Stadium |
| 2021-08-07 10:30:00August 7, 2021 | Shining Stars FC vs Mafred United FC | 10:30:0010:30 am | Eziphunzini Ground |
| 2021-08-07 10:30:00August 7, 2021 |  Greenfield Rangers FC vs Mangosuthu Cosmos FC | 10:30:0010:30 am | Masenkeni Stadium |
| 2021-08-07 12:00:00August 7, 2021 |  Madola United FC vs Comet Riders FC | 12:00:0012:00 pm | Eziphunzini Ground |
| 2021-08-07 12:00:00August 7, 2021 | Thandolokukhanya FC vs Mara Mara FC | 12:00:0012:00 pm | Masenkeni Stadium |
| 2021-08-07 13:30:00August 7, 2021 | Welverdiend Stars FC vs Bayern Munich FC | 13:30:001:30 pm | Eziphunzini Ground |
| 2021-08-07 13:30:00August 7, 2021 |  Silver Stars FC vs First Touch FC | 13:30:001:30 pm | Masenkeni Stadium |
| 2021-08-07 15:00:00August 7, 2021 |  PR Barcelona FC vs Total Football United FC | 15:00:003:00 pm | Masenkeni Stadium |
| 2021-08-08 09:00:00August 8, 2021 | Mara Mara FC vs Paris St. Germain FC | 09:00:009:00 am | Kwantombazana Ground |
| 2021-08-08 09:00:00August 8, 2021 | Comet Riders FC vs Shining Stars FC | 09:00:009:00 am | Masenkeni Stadium |
| 2021-08-08 10:30:00August 8, 2021 | Thandolokukhanya FC vs PR Barcelona FC | 10:30:0010:30 am | Kwantombazana Ground |
| 2021-08-08 10:30:00August 8, 2021 | Bayern Munich FC vs Greenfield Rangers FC | 10:30:0010:30 am | Masenkeni Stadium |
| 2021-08-08 12:00:00August 8, 2021 | Young Zebras FC vs Madola United FC | 12:00:0012:00 pm | Kwantombazana Ground |
| 2021-08-08 12:00:00August 8, 2021 | Mafred United FC vs Citizen FC | 12:00:0012:00 pm | Masenkeni Stadium |
| 2021-08-08 13:00:00August 8, 2021 | Losta Stars Ladies FC vs Sasol Juventus Ladies FC | 13:00:001:00 pm | Masenkeni Stadium |
| 2021-08-08 13:00:00August 8, 2021 | Leandra United FC vs Saint Mary's Ladies FC | 13:00:001:00 pm | Leandra Stadium |
| 2021-08-08 13:00:00August 8, 2021 | FC Royal Knights vs Silindile Ladies FC | 13:00:001:00 pm | New Denmark Ground |
| 2021-08-08 13:00:00August 8, 2021 | Chosen Few FC vs Two Touch FC | 13:00:001:00 pm | Siyazenzela Stadium |
| 2021-08-08 13:30:00August 8, 2021 | Total Football United FC vs Welverdiend Stars FC | 13:30:001:30 pm | Kwantombazana Ground |
| 2021-08-08 13:30:00August 8, 2021 | Mangosuthu Cosmos FC vs Silver Stars FC | 13:30:001:30 pm | Masenkeni Stadium |
| 2021-08-08 15:00:00August 8, 2021 | Mangosuthu Sundowns FC vs First Touch FC | 15:00:003:00 pm | Masenkeni Stadium |